Minimizing the diagnosis of “follicular lesion of undetermined significance” and identifying predictive features for neoplasia

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Minimizing the diagnosis of "follicular lesion of undetermined significance" and identifying predictive features for neoplasia.

We used proposed standard morphologic criteria as a guideline to conduct a 10-year retrospective review of thyroid fine-needle aspiration specimens that were originally interpreted as "follicular lesion of undetermined significance" and followed by surgical intervention. We sought to investigate whether the indeterminate diagnosis could be minimized by assessing various cytomorphologic features...

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Group consensus review minimizes the diagnosis of "follicular lesion of undetermined significance" and improves cytohistologic concordance.

We conducted a group consensus review of thyroid aspirates that were previously interpreted as "atypia of undetermined significance/follicular lesion of undetermined significance" (AUS/FLUS) and followed by surgical interventions. The study aimed to investigate if consensus review would minimize the diagnosis of AUS/FLUS with an optimal interobserver agreement and also promote a better cytohist...

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Atypia of Undetermined Significance/Follicular Lesion of Undetermined Significance (AUS/FLUS): Interpretation and Algorithm for Follow-Up

The Bethesda System for Reporting Thyroid Cytology (TBSRTC) has proven to be an effective and robust thyroid fine needle aspiration (FNA) classification scheme to guide the clinical treatment of patients with thyroid nodules. However, a tendency of increasing diagnosis of atypia of undetermined significance/follicular lesion of undetermined significance (AUS/FLUS) is observed. This is commensur...

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Follicular Lesion of Undetermined Significance in Thyroid FNA--How Is It Used? Implications of the Proposed Thyroid Fine-Needle Aspiration Category of "Follicular Lesion of Undetermined Significance":

Background: Fine-needle aspiration (FNA) is the current standard for triaging patients with thyroid nodules into operative and nonoperative therapy. In 2007, the National Cancer Institute (NCI) held a Thyroid FNA State of the Science Conference, where a 6-tiered classification system was proposed to standardize reporting of thyroid FNA results. One category, designated "follicular lesion of und...

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ژورنال

عنوان ژورنال: Diagnostic Cytopathology

سال: 2010

ISSN: 8755-1039

DOI: 10.1002/dc.21459